The Mechanism of the Anti-Inflammatory Activity of Salicylate

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Abstract
Salicylate reduced the leakage of circulating dye in the reversed passive cutaneous anaphylaxis reaction in the guinea pig. 2,4-Dinitrophenol, although a more powerful uncoupling reagent than salicylate, had no effect compared to corresponding control animals. In this test in the guinea-pig, salicylate inhibits the increased capillary permeability due to cutaneous anaphylaxis and to histamine, but not to Miles-Wilhelm permeability factor. It is concluded that the effect of salicylate in reducing the increased capillary permeability produced in these reactions does not result from an uncoupling action on oxidative phosphorylation processes. The results suggest that salicylates act by preventing antigen-antibody combinations from exerting their effects on the capillary wall.