Relation of Induced Sulfonamide Resistance to Biochemical Properties in Alpha Streptococci

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Abstract
Loss of ability to produce H2O2 accompanied acquisition of resistance to sulfathiazole in o strains of alpha-streptococci. Other biochemical changes including dehydrogenase activity for glucose, glycerol, pyruvate, and lactate, indicated an overall increase in metabolic activity. The 4 strains that were unable to grow on 40% bile agar required riboflavin for growth. After becoming resistant, they were found to be synthesizing riboflavin. No catalase, or cytochrome c-cyto-chrome oxidase system was found in the resistant organisms which might have explained the lowered peroxide production. A possible mechanism for the resistance is suggested.

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