Effect of lodination on the Biological Activity of Insulin

1 January 1972

journal article
research article
Published by Georg Thieme Verlag KG in Hormone and Metabolic Research

Vol. 4 (03) , 149-151
https://doi.org/10.1055/s-0028-1094089

Abstract

The preparation of pure ¹²⁵I-monoiodoinsulin is described. This iodohormone has lost its capacity to stimulate the glucose uptake by rat diaphragm, nevertheless it binds to the plasmatic receptors and competes with unlabeled insulin.

Keywords

MONOIODOINSULIN
BIOACTIVITY
BINDING CONSTANTS
INHIBITORY EFFECT