EXPERIMENTAL INVESTIGATIONS OF A PROPHYLACTIC EFFECT OF TRIBENOSIDE UPON SPONTANEOUS OSTEO-ARTHROSIS OF MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 36  (3-4) , 112-119
Abstract
Tribenoside, a D-glucofuranose derivative, was administered prophylactically over a period of 10 mo. to 6 mo. old mice of the C 57 Black strain which are known to have a predisposition to spontaneous gonarthrosis. The preparation was given once daily for 5 consecutive days every other week in doses of 100 or 300 mg/kg orally. At the end of the treatment period, serial sections of both knee joints were examined. In the placebo-treated controls arthrotic lesions of varying severity were found in 97% of the specimens. In the animals given tribenoside in either dosage arthortic lesions were significantly less frequent and less severe. The number of animals with bilateral gonarthrosis and proliferative changes was also significantly or highly significantly smaller in the groups treated with tribenoside than in the controls. The only indication of a dose-related effect of the preparation was that arthrosis of the most severe grade was present in fewer animals in the group treated with the higher dose. The mechanism of action responsible for the protective effect of tribenoside cannot be clearly defined.