Use of a Desk-Top Computer in a Search-Type Optimization of Tablet Formulations
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 6 (4) , 311-330
- https://doi.org/10.3109/03639048009068708
Abstract
The use of a desk-top computer in the field of formulation and process optimization is described. To illustrate an application of this technique, a series of tablets has been prepared according to a classical optimization design to determine the optman levels of process variables which meet pre-established specifications for product variables (hardness, thickness, etc.) based on second order polynomial predictor equations for each measured parameter.This publication has 3 references indexed in Scilit:
- Selecting Key Pharmaceutical Formulation Factors by Regression AnalysisDrug Development and Industrial Pharmacy, 1979
- Computer Optimization of Pharmaceutical Formulations I: General procedureJournal of Pharmaceutical Sciences, 1973
- Mathematical Optimization Techniques in Drug Product Design and Process AnalysisJournal of Pharmaceutical Sciences, 1970