GADOLINIUM ENHANCED NUCLEAR MAGNETIC-RESONANCE IMAGES OF EXPERIMENTAL BRAIN-ABSCESS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 8  (2) , 204-207
Abstract
Gd-DTPA [diethylenetriaminepentaacetic acid], a paramagnetic contrast agent that distributes throughout the body in a manner similar to diatrizoate, was i.v. administered to a monkey [Cynomolgus] with a hematogenously induced experimental intracranial abscess. Contrast enhanced computed tomography (CT) and Gd enhanced saturation-recovery NMR were both performed immediately and repeated after a 30 min delay. The NMR images revealed marked ring enhancement at a time when CT showed a nodule. Both imaging modalities were analyzed with respect to the pathological specimen. Gd-DTPA may be an effective agent for imaging alterations of the blood-brain barrier.

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