THE ACTION OF LEAD ON PHOSPHOCREATINE IN THE MUSCULAR PARALYSIS OF LEAD POISONING

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Abstract
Phosphate changes were studied in muscles of normal and lead-poisoned frogs. Normally, the phosphocreatine hydrolyzed during a 2-min. tetanus was completely resynthesized after 1/2-hr. recovery period. The resting level of phosphocreatine in the muscles of poisoned animals was much lower than the normal value, while the inorganic phosphate was greatly increased. At the end of a 1/2-hr. recovery, there was practically no re-synthesis of the phosphocreatine hydrolyzed during a 2-min. tetanus of the Pb-poisoned muscle. There was a loss of in-organic phosphate from the poisoned muscle due to the increase in inorganic phosphate content of the muscle as a result of the hydrolysis of phosphocreatine. Muscles immersed in oxygenated Ringer containing Pb have a lower phosphocreatine value and a higher inorganic phosphate content than control muscles. The increase in the rate of diffusion of phosphate from a muscle in Pb-Ringer was explained by the increase in inorganic phosphate which set up a greater diffusion gradient.

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