Lead development: Validation and application of high throughput screening for determination of pharmacokinetic parameters for enzyme inhibitors
- 31 May 1996
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 4 (5) , 639-643
- https://doi.org/10.1016/0968-0896(96)00057-0
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol coresJournal of Medicinal Chemistry, 1995
- Inhibition of Matrix Metalloproteinases by Hydroxamates Containing Heteroatom-Based Modifications of the P1' GroupJournal of Medicinal Chemistry, 1995
- Expedient Method for the Solid-Phase Synthesis of Aspartic Acid Protease Inhibitors Directed toward the Generation of LibrariesJournal of Medicinal Chemistry, 1995
- Relationship between structure and bioavailability in a series of hydroxamate based metalloprotease inhibitorsBioorganic & Medicinal Chemistry Letters, 1995
- Validation of Screening Immobilized Peptide Libraries for Discovery of Protease SubstratesJournal of Medicinal Chemistry, 1995
- Comparison of Native Matrix Metalloproteinases and Their Recombinant Catalytic Domains Using a Novel Radiometric AssayArchives of Biochemistry and Biophysics, 1994
- Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future DirectionsJournal of Medicinal Chemistry, 1994
- Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3-[[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-72517)Journal of Medicinal Chemistry, 1993
- Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptidesJournal of Medicinal Chemistry, 1993