Receptor-Operated Calcium Influx Mediated by Protein Tyrosine Kinase Pathways
- 1 January 1998
- journal article
- review article
- Published by Taylor & Francis in Journal of Receptors and Signal Transduction
- Vol. 18 (4-6) , 281-310
- https://doi.org/10.3109/10799899809047748
Abstract
Calcium influx from the extracellular space elicited by activation of heterotrimeric G protein-coupled and heptahelical receptors plays a critical role in transmembrane signal transduction in a wide variety of cell systems. In nonexcitable cells, the precise voltage-independent mechanism by which calcium enters the cell remains unknown. Multiple mechanisms appear to be operating in different cell types (1-3): 1. G protein-operated calcium influx, 2. Second messenger-operated calcium influx, 3. Capacitative calcium influx, and 4. Phosphorylation of calcium channels. Receptor-operated calcium channels have a fundamental role in stimulus-secretion coupling in many different cells, but these channels remain to be purified and cloned. This review proposes that receptor-operated calcium influx is mediated by protein tyrosine kinase pathways. The function of protein tyrosine kinase pathways and their interactions with other receptor-operated calcium influx mechanisms are described.Keywords
This publication has 91 references indexed in Scilit:
- Src Kinase Pathways in Extracellular Ca2+-Dependent Pancreatic Enzyme SecretionBiochemical and Biophysical Research Communications, 1996
- Doc2: A Novel Brain Protein Having Two Repeated C2-like DomainsBiochemical and Biophysical Research Communications, 1995
- Tyrosine Kinase Inhibitors Attenuate "Capacitative" Ca2+ Influx in Rat Pancreatic Acinar CellsBiochemical and Biophysical Research Communications, 1994
- Localization of Rabphilin-3A on the Synaptic VesicleBiochemical and Biophysical Research Communications, 1994
- Mode-switching of a voltage-gated cation channel is mediated by a protein kinase A-regulated tyrosine phosphataseNature, 1993
- Muscarinic Receptors Stimulate Ca2+ Influx via Phospholipase A2 Pathway in Ileal Smooth MusclesBiochemical and Biophysical Research Communications, 1993
- Genistein, a Tyrosine Kinase Inhibitor, Blocks the Cell Cycle Progression but not Ca2+ Influx Induced by BAY K8644 in FRTL-5 CellsBiochemical and Biophysical Research Communications, 1993
- Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cellsBiochemical and Biophysical Research Communications, 1992
- Isoflavonoids, genistein, psi-tectorigenin, and orobol, increase cytoplasmic free calcium in isolated rat hepatocytesBiochemical and Biophysical Research Communications, 1992
- Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family.The Journal of cell biology, 1991