Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridization
- 1 August 1993
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 7 (4) , 204-208
- https://doi.org/10.1002/gcc.2870070404
Abstract
Fluorescence in situ hybridization (FISH) was performed on bone marrow or peripheral blood cells thought to contain a del(11)(q23q25) from four patients who had acute leukemia or myelodysplasia. Cells from all patients were shown to contain translocations that involved chromosome 6 in three of them. Our data suggest that a large proportion of presumptive del(11)(q23) or del(11)(q23q25) chromosomes may represent previously unidentified translocations that can be detected by FISH.Keywords
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