DETECTION OF PLACENTAL PROTEIN-5 (PP5) AND PREGNANCY-SPECIFIC GLYCOPROTEIN (SP1) IN BENIGN AND MALIGNANT BREAST DISEASE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 2  (1-2) , 55-62
Abstract
Sensitive radioimmunoassays for the placental proteins PP5 and SP1 were used to investigate possible ectopic synthesis of these proteins by breast tumors. Elevated serum levels of the proteins were found in a small proportion of patients who had undergone mastectomy for malignant tumors, but little useful information on tumor spread could be gained from such measurements. In 2 patients with elevated preoperative serum PP5, the levels fell to normal upon resection of the tumor, suggesting that PP5 may be a product of the tumor. PP5 and SP1 were present in the majority of homogenates of malignant and benign breast lesions; the highest concentrations of SP1 were found in malignant tumors, whereas with PP5, especially high levels were found in cases of simple cystic disease.