Colcemid sensitivity of fission yeast: permeability and detoxification properties of resistant mutants

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Abstract
Mutants of Schizosaccharomyces pombe, which were resistant to concentrations of colcemid inhibitory to the wild-type parent, were not diminished in their permeability to colcemid or colchicine. They did not modify colcemid to a detectable derivative or to a product that was incapable of binding to brain tubulin [rat]. The resistance of these mutants was therefore via mechanisms different from those of permeability and detoxification known for animal cells.