Materials Science of the Gel to Fluid Phase Transition in a Supported Phospholipid Bilayer
- 21 November 2002
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 89 (24) , 246103
- https://doi.org/10.1103/physrevlett.89.246103
Abstract
We report the results of in situ AFM measurements examining the phase transition of bilayers formed from the zwitterionic phospholipid, DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine, supported on mica. The images show that the fluid to gel phase transition process features substantial tearing of the bilayer due to the density change between the two phases. The gel to fluid transition is strongly affected by the resultant stress introduced into the gel phase, which changes the degree of cooperativity, the shape of developing fluid phase regions, and the course of the transition.Keywords
This publication has 16 references indexed in Scilit:
- Fluctuations caught in the actNature, 2000
- Creating Spatially Addressed Arrays of Planar Supported Fluid Phospholipid MembranesJournal of the American Chemical Society, 1999
- Conformation and Self-Diffusion of Single DNA Molecules Confined to Two DimensionsPhysical Review Letters, 1999
- Coexistence of Buckled and Flat MonolayersPhysical Review Letters, 1998
- A magnetically driven oscillating probe microscope for operation in liquidsApplied Physics Letters, 1996
- Supported Membranes: Scientific and Practical ApplicationsScience, 1996
- Progress in high resolution atomic force microscopy in biologyQuarterly Reviews of Biophysics, 1995
- Structure of an adsorbed dimyristoylphosphatidylcholine bilayer measured with specular reflection of neutronsBiophysical Journal, 1991
- Allogeneic stimulation of cytotoxic T cells by supported planar membranes.Proceedings of the National Academy of Sciences, 1984
- Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry.Proceedings of the National Academy of Sciences, 1976