An Improved Synthesis of 3,4,6-Tri-O-acetyl-2-azido-2-deoxy-α-d-galactopyranosyl Bromide: A Key Component for Synthesis of Glycopeptides and Glycolipids
- 1 January 1994
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 13 (1) , 129-132
- https://doi.org/10.1080/07328309408009183
Abstract
Results and discussion The α-glycosidic bond between N-acetylgalactosamine and serine or threonine is one of the most important linkages between the carbohydrate and peptide parts of O-glycoproteins.1 This linkage is found in mucous glycoproteins and is also a characteristic of many serum and membrane bound glycoproteins, including proteins containing the tumour associated TN and T antigens. α-O-Glycosidically linked N-acetylgalactosamine also occurs in the blood group A determinant2 and in glycolipids such as the Forssman antigen.3Keywords
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