Effect of Phenylephrine on Cardiac Contractility and Adenyl Cyclase Activity

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Abstract
Both phenylephrine and noradrenaline increased the force of contraction of isolated preparations of rabbit and chicken heart. Noradrenaline increased the rate of formation of cyclic 3′,5′-AMP in homogenate of rabbit or chicken heart, but phenylephrine did not. These results demonstrate that sympathomimetic amines can increase cardiac contractility without increasing the activity of adenyl cyclase.