Complement fixation by IgM and IgG autoantibodies on cultured human glial cells

Publisher Website
Google Scholar
Abstract
The humoral immune response to autologous gliomas was investigated in 16 patients using immune adherence and anti-C3 [complement component 3] immunofluorescence assays of serum samples. Significant anti-glioma antibody activity was detected in 56% of these sera. Fractionation experiments demonstrated that IgM class antibodies were more effective than IgG in their ability to fix C on cultured glioma cell membranes. Autologous IgG inhibited IgM complement-fixing activity in some experiments. Capping of immune complexes on the glioma cell surface is also described.