Origin of the “Light Cells” of the Thyroid Gland

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Abstract
The light cells of the thyroid gland of the rat increase in number after treatment with somatotropic hormone and after hypophysectomy. Investigation was made to determine whether or not, under these 2 conditions, the mitotic rate of light cells accounted for this growth. While the presence of a few mitotic light cells indicated that some light cells originated from light cells, it was found that their rate of proliferation was much too low to account for the overall growth of the light cell population. It was concluded that, in the experimental conditions used, most newly appearing light cells originated from other cells present in the thyroid gland, presumably from the follicular cells. According to this concept, light cells would be “modulated” follicular cells.
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