Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts
- 18 September 2005
- journal article
- Published by Springer Nature in Nature Medicine
- Vol. 11 (10) , 1056-1058
- https://doi.org/10.1038/nm1288
Abstract
Dysfunction of receptors for IgG (FcgammaRs) has been thought to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We show that a recently described SLE-associated polymorphism of FcgammaRIIb (FcgammaRIIbT(232)), encoding a single transmembrane amino acid substitution, is functionally impaired. FcgammaRIIbT(232) is unable to inhibit activatory receptors because it is excluded from sphingolipid rafts, resulting in the unopposed proinflammatory signaling thought to promote SLE.Keywords
This publication has 15 references indexed in Scilit:
- The inhibitory Fcγ receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cellsNature Immunology, 2004
- Autonomous SHIP-dependent FcγR signaling in pre-B cells leads to inhibition of cell migration and induction of cell deathImmunology Letters, 2004
- FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of SepsisThe Journal of Experimental Medicine, 2004
- A novel polymorphism in the Fcγ receptor IIB (CD32B) transmembrane region alters receptor signalingArthritis & Rheumatism, 2003
- Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcγRIIbImmunology Letters, 2002
- Roles of Fc receptors in autoimmunityNature Reviews Immunology, 2002
- Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution of FCGR2B to genetic susceptibilityArthritis & Rheumatism, 2002
- Cholesterol-modulating Agents Selectively Inhibit Calcium Influx Induced by Chemoattractants in Human NeutrophilsJournal of Biological Chemistry, 2002
- Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific EpistasisImmunity, 2000
- Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domainThe EMBO Journal, 1997