PROPHYLACTIC ADMINISTRATION OF PENICILLIN TO OBSTETRIC PATIENTS

4 February 1950

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 142 (5) , 324-328
https://doi.org/10.1001/jama.1950.02910230026007

Abstract

A previous communication¹recorded our experience with the prophylactic administration of penicillin to women during labor and shortly after delivery between Feb. 3, 1947 and Jan. 31, 1948. In that study a control group of 430 patients was compared with two treated series given 600,000 (202 women) and 900,000 units (263 women) of penicillin. Patients were grouped alternately according to their admission to the labor rooms. Women delivered abdominally and those receiving penicillin therapeutically for any reason were excluded, but no other selection was employed. Penicillin suspended in beeswax and oil was used for the first ten months, but subsequent to that date penicillin G in oil and wax was utilized. The two groups showed a distribution according to parity, financial status, incidence of operative intervention and gestational and parturitional complications similar enough to make comparisons reasonably valid. The penicillin-treated group showed no significant reduction in intrapartum fevers or

Keywords

PENICILLIN

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