Thymus-Derived Lymphocytes in Patients With Bilharzial Urinary Bladder Cancer: Brief Communication

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Abstract
The purpose of the present study was to determine the levels of peripheral blood thymus-derived (T) lymphocytes in a series of 43 Egyptian patients with bilharzial bladder cancer and 15 with chronic bilharziasis and to compare these to normal Egyptian controls. Both active and total T-cell rosettes were significantly reduced in patients with stages III and IV bladder cancer, whereas only total T-cell rosettes were reduced in patients with stages I and II disease when compared to normal controls. Patients with chronic bilharziasis had intermediate values between those with cancer and normal controls, but this difference was significant only for total T-cell rosettes. Only those patients with advanced disease (stages III and IV) had significantly lower percentages of active T-lymphocytes when compared to patients with bilharziasis. Since total T-cell levels were reduced significantly in cancer patients with both early (stages I and II) and advanced (stages III and IV) disease when compared to normal controls and patients with bilharziasis, only the number of active T-cells could be correlated with the clinical stage of disease.

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