Intestinal Transport of Carbohydrates as Measured by Portal Catheterization in Man

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Abstract
A method for studying the transport of an intraduodenally instilled solution of carbohydrates by simultaneous sampling of portal and arterial blood is described. The transport of glucose, maltose and fructose was measured in ambulant adult patients with cancer of the colon without liver metastases. They were in a normal nutritional state. 200 ml of a 6-percent carbohydrate solution was instilled intraduodenally within 10 min. Portal glucose rise was not slower after instillation of maltose than after that of glucose. Transport of fructose was completed somewhat later than that of glucose. The difference in the portal-arterial blood sugar concentration was used as a measure of the actual net influx of carbohydrates into the portal circulation at certain intervals. After instillation of glucose or maltose the portal-arterial glucose difference showed two maxima. The interposed minimum often reached a slightly negative value. It is tentatively assumed that this unexpected finding was due to accumulation of glucose in the intestinal mucosa, followed by a release of the accumulated glucose coinciding with the subsequent fall of arterial blood glucose concentration. Absorbed fructose was not found to behave in the same manner. Although some transformation of fructose to glucose during transport through the intestinal wall may have occurred, it was less than could be detected in these experiments.

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