ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates
- 1 October 2009
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 53 (10) , 4504-4507
- https://doi.org/10.1128/aac.00556-09
Abstract
The in vitro activity of ACHN-490, a novel aminoglycoside ("neoglycoside"), was evaluated against 102 multidrug-resistant (MDR) Klebsiella pneumoniae strains, including a subset of 25 strains producing the KPC carbapenemase. MIC50 values for gentamicin, tobramycin, and amikacin were 8 mu g/ml, 32 mu g/ml, and 2 mu g/ml, respectively; MIC90 values for the same antimicrobials were >= 64 mu g/ml, >= 64 mu g/ml, and 32 mu g/ml, respectively. ACHN-490 showed an MIC50 of 0.5 mu g/ml and an MIC90 of 1 mu g/ml, which are significantly lower than those of comparator aminoglycosides. ACHN-490 represents a promising aminoglycoside for the treatment of MDR K. pneumoniae isolates, including those producing KPC beta-lactamase.Keywords
This publication has 24 references indexed in Scilit:
- Early Dissemination of KPC-2-Producing Klebsiella pneumoniae Strains in BrazilAntimicrobial Agents and Chemotherapy, 2009
- Detection of Plasmid-Mediated KPC-Producing Klebsiella pneumoniae in Ottawa, Canada: Evidence of Intrahospital TransmissionJournal of Clinical Microbiology, 2009
- Decreased Susceptibility to Polymyxin B during Treatment for Carbapenem-Resistant Klebsiella pneumoniae InfectionJournal of Clinical Microbiology, 2009
- Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece)Journal of Infection, 2009
- Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USAJournal of Antimicrobial Chemotherapy, 2009
- Presence of Plasmid-Mediated Quinolone Resistance in Klebsiella pneumoniae Isolates Possessing bla KPC in the United StatesAntimicrobial Agents and Chemotherapy, 2008
- Novel Plasmid-Mediated 16S rRNA m 1 A1408 Methyltransferase, NpmA, Found in a Clinically Isolated Escherichia coli Strain Resistant to Structurally Diverse AminoglycosidesAntimicrobial Agents and Chemotherapy, 2007
- Carbapenemases: the Versatile β-LactamasesClinical Microbiology Reviews, 2007
- Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. Isolates from Military and Civilian Patients Treated at the Walter Reed Army Medical CenterAntimicrobial Agents and Chemotherapy, 2006
- Prevalence and antimicrobial susceptibility data for extended-spectrum β-lactamase– and AmpC-producing Enterobacteriaceae from the MYSTIC Program in Europe and the United States (1997–2004)Diagnostic Microbiology and Infectious Disease, 2005