Biliary conjugated metabolites of estriol in the rat.

Publisher Website
Google Scholar
Abstract
Isolation and characterization of the conjugated metabolites excreted in rat bile following the oral administration of a large dose of estriol [an agent given for clinical states associated with the climacteric] was undertaken. The principal conjugates were separated by chromatography on Amberlite XAD-2 resin, followed by gel filtration on Sephadex LH-20 and partition chromatography on silica gel. The structures of these metabolites were deduced from the physico-chemical data and definitely characterized by leading to the known derivatives and their comparison with the synthetic specimens. The physiological significance of biotransformation hereby observed was also discussed.

This publication has 4 references indexed in Scilit: