Intraventricular administration of isoproterenol inhibits both heat production and heat loss mechanisms in rats

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Abstract
At an ambient temperature (Ta) of 8°C, intraventricular administration of isoproterenol inhibited metabolic heat production and led to hypothermia in rats. In contrast, at a Ta of 22°C and of 30°C, isoproterenol decreased cutaneous circulation and led to hyperthermia. The data indicate that isoproterenol inhibits both heat production and heat loss mechanisms in rats.