Selective Inhibition of Adhesion Molecule Expression by Edelf osine (ET-18-OCH3) on Human Umbilical Vein or Microvascular Endothelium
- 1 January 1995
- journal article
- research article
- Published by S. Karger AG in Pathobiology
- Vol. 63 (2) , 109-114
- https://doi.org/10.1159/000163941
Abstract
An abundance of data is accumulating that suggest that if one can block endothelial cell-leukocyte binding or inhibit cell adhesion molecules (CAM), inflammatory events can be greatly diminished. In this report, we demonstrate that an alkyl-lysophospholipid compound (ET-18-OCH3) can decrease adhesion molecule expression on cultured human micro- and macrovascular endothelial cell lines. ET-18 selectively decreased CAM expression; CD31 was decreased, however. Vascular CAM-1 tumor necrosis factor-α-induced expression was not altered. Intercellular adhesion molecule 1 expression was decreased, but endoglin expression was not affected. Thus, we have demonstrated nontoxic downmodulation of vascular CAM expression in vitro. Whether this compound will have anti-inflammatory properties needs to be clarified in animal models.Keywords
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