Anticoagulant Effect of Various Snake Toxins in vitro

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Abstract
Seven out of 14 examined snake venoms showed an inhibitory effect on the coagulation of plasma in vitro. A number of principles participate in this effect, acting in different phases of the clotting mechanism. It can not only be explained by fibrinolysis, denaturation of fibrinogen or splitting of the lipoid factors of coagulation. It could be shown that the intervention into the conversion of prothrombin is of greatest importance probably by lowering the prothrombin level brought about by non-specific proteases. The prothrombinolytic and inhibitory components of various venoms are not identical because they resist to heat denaturation in a different manner. Moreover all anticoagulant venoms proved to contain a thromboplastic thermostable component, the effect of which is influenced by calcium and is potentiated by kephalin.

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