THE EXPERIMENTAL INDUCTION OF OESTRUS (SEXUAL RECEPTIVITY) IN THE NORMAL AND OVARIECTOMIZED GUINEA PIG

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Abstract
14% of injections of 1000 I.U. theelin in 21 normal [female] guinea pigs and 31% of 54 injections in spayed [female][female] were followed by sexual receptivity. The latent period averaged 35.3 hrs. Intraven. inj. of 0.2 gm. equivalents of sheep luteinizing hormone produced heat and ovulation in 19 of 24 cases when injected into normal animals on the 12th to 15th day of the cycle, but were ineffective earlier in 15 cases. The latent period averaged 5.8 hrs. Similar injections of luteinizer in spayed animals were ineffective, and the combination of oestrin and luteinizer did not enhance the efficiency of the oestrin in 15 cases. Injections of 40 I.U. or more of oestrin, followed 36-48 hrs. later by 0.2 I.U. progesterone invariably produced heat in 24 spayed [female][female]. The latent period averaged 4.8 hrs. after the injection of the progesterone. 7 of 9 normal animals injected with progesterone alone on the 14th or 15th day came into heat 5-10 hrs. later, but did not ovulate.[long dash]It is postu lated that after conditioning with oestrin, oestrus in the guinea pig is caused by progesterone which is produced during the preovulatory swelling by the still un-ruptured follicle.

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