Retardation by Methylprednisolone of the Synergistic Toxicity of Endotoxin with Sparsomycin or Pactamycin

Publisher Website
Google Scholar
Abstract
Summary A large dose of methylprednisolone (100 mg/kg) given to mice 1 hr before challenge with sparsomycin and bacterial endotoxin significantly prolonged their survival time. The same dose of methylprednisolone given 1 hr before challenge with pactamycin and bacterial endotoxin protected mice against the synergistic toxicity. Phenylbutazone (120 mg/kg) and chlorpheniramine (4 mg/kg) failed to diminish the toxicity of the pactamycin-endotoxin synergy. Sparsomycin, pactamycin, phenylbutazone, and 6α-methylprednisolone (Medrol) were generously supplied by Dr. G. S. Fonken, The Upjohn Company, Kalamazoo, Michigan.

This publication has 0 references indexed in Scilit: