EXPRESSION OF OKT 8 ANTIGEN AND Fcγ RECEPTORS BY SUPPRESSOR CELLS MEDIATING SPECIFIC UNRESPONSIVENESS BETWEEN RECIPIENT AND DONOR IN RENAL-ALLOGRAFT-TOLERANT PATIENTS

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Abstract
Renal allograft tolerant patients show specific unresponsiveness in mixed-lymphocyte culture assays when confronted with donor stimulating cells. Separation of posttransplant peripheral blood lymphocytes into Fe γ+ and Fc γ- by rosetting and into OKT8+, OKT8- by cytofluorometry enabled the demonstration of normal responses by Fc γ- and OKT8- cells, whereas the proliferation of OKT8+ and Fc γ+ cells was depressed specifically in the presence of donor cells. Using mixing experiments, we showed that OKT8+ and Fc γ+ posttransplant lymphocytes exert a suppressive effect specific to the donor-recipient pair on the proliferative response of the pretransplant lymphocytes.

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