Feeding‐Induced Changes in Energy Expenditure in Children With Cystic Fibrosis

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Abstract
Seven children with cystic fibrosis (aged 7 to 12 years) were studied in the fasted and fed states. Using a primed, constant, intravenous infusion of NaH13CO3, the rate of appearance of CO2 (RaCO2) was estimated. Net CO2 excretion (VCO 2) was also measured. Energy expenditure was calculated using the food quotient. RaCO2 (mean ± SD) (μmol·kg-1·min -1) in the fasted and fed states (297 ± 59 and 359 ± 67) was 117% and 105% of VCO2 (259 ±48 and 352 ± 72). Feeding induced a 23% and a 37% increase in RaCO2 and VCO2, respectively, and respective 19% and 33% increases in energy expenditure (p < .05). Measurement of CO2 production by isotopic dilution is a useful index of group changes in energy expenditure, including those induced by feeding. (Journal of Parenteral and Enteral Nutrition18:497-502, 1994)