Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation
Open Access
- 6 April 2005
- journal article
- fj express-summaries
- Published by Wiley in The FASEB Journal
- Vol. 19 (8) , 977-979
- https://doi.org/10.1096/fj.04-2765fje
Abstract
Uncoupling protein 3 (UCP3) expression is directly correlated to fatty acid oxidation in skeletal muscle. UCP3 has been hypothesized to facilitate high rates of fatty acid oxidation, but evidence thu...Keywords
Funding Information
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
This publication has 50 references indexed in Scilit:
- Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-α-regulated gene in cardiac and skeletal muscleAmerican Journal of Physiology-Endocrinology and Metabolism, 2004
- Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?International Journal of Obesity, 2004
- Uncoupling protein 3 as a mitochondrial fatty acid anion exporterThe FASEB Journal, 2003
- Plasmalemmal fatty acid transport is regulated in heart and skeletal muscle by contraction, insulin and leptin, and in obesity and diabetesActa Physiologica Scandinavica, 2003
- Fasting, lipid metabolism, and triiodothyronine in rat gastrocnemius muscle: interrelated roles of uncoupling protein 3, mitochondrial thioesterase, and coenzyme QThe FASEB Journal, 2003
- Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscleThe Journal of Physiology, 2003
- Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid versus glucose oxidationThe FASEB Journal, 2001
- A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeastBiochemical Journal, 2001
- Carnitine palmitoyl transferase I and the control of myocardial β-oxidation fluxBiochemical Society Transactions, 2001
- Genomic Organization and Regulation by Dietary Fat of the Uncoupling Protein 3 and 2 GenesBiochemical and Biophysical Research Communications, 1999