1α,25(OH)2Vitamin D3-Regulated Expression of the Eukaryotic Genome
- 27 April 2009
- journal article
- review article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 52 (11) , 376-382
- https://doi.org/10.1111/j.1753-4887.1994.tb01368.x
Abstract
1α,25(OH)2vitamin-D3, [1α,25(OH)2D3] is a potent steroid hormone that produces a wide array of biologic effects in a variety of target tissues within the body through its ability to modulate gene transcription of specific target genes. Evidence for transcription regulation of a specific gene typically includes 1α,25(OH)2D3-induced modulation in mRNA levels. Additionally, evidence may include measurements of transcription and or the presence of a vitamin D response element within the promoter region of the gene. To date, over 50 genes have been reported to be transcriptionally regulated by 1α,25(OH)2D3- We present a current list of these genes and the evidence supporting their inclusion on the list.Keywords
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