Combined Action of Sulphamethoxazole and Trimethoprim Against Clinically-Isolated Sulphonamide–Resistant Bacteria
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 25 (5) , 296-302
- https://doi.org/10.1159/000237854
Abstract
42 strains of gram-negative bacteria, isolated from clinical material, resistant to trimethoprim (TM), sulphamethoxazole (SMZ) or both, have been tested for synergistic sensitivity to TM + SMZ. The combination showed no synergy against strains ‘highly resistant’ to SMZ (MIC > 1 mg/ml). Indifference was invariably observed. However, synergy was seen with strains ‘moderately resistant’ to SMZ (MIC 100–1,000 ug/ml). Our results indicate that present techniques for the testing of urinary tract isolates for sensitivity to co-trimoxazole need revision.Keywords
This publication has 1 reference indexed in Scilit:
- Sensitivity of Pseudomonas Aeruginosa To Sulphonamides and Trimethoprim and the Activity of the Combination Trimethoprim: SulphamethoxazoleJournal of Medical Microbiology, 1977