The syntheses and biological properties of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B.

1 January 1978

journal article
research article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 31 (7) , 681-687
https://doi.org/10.7164/antibiotics.31.681

Abstract

The syntheses of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B, designated Sch 20287 and Sch 21420, respectively, by procedures similar to those developed by Kawaguchi and co-workers for the transformation of kanamycin A to amikacin are described. The in vitro microbiological [antibacterial] properties of Sch 20287 and Sch 21420 are compared with amikacin, gentamicin and tobramycin.