Regulation of the Protein Kinase Activity of the Human Insulin Receptor
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Journal of Receptor Research
- Vol. 7 (1-4) , 405-415
- https://doi.org/10.3109/10799898709054995
Abstract
The insulin receptor is a hormone-dependent protein tyrosine kinase that belongs to the family of tyrosine kinases associated with growth factor receptors and oncogene products. The activity of the insulin receptor kinase is regulated by the phosphorylation state of specific domains of the protein. Phosphorylation of the receptor on tyrosine residues activates its kinase activity whereas phosphorylation on serine and/or threonine residues inhibits it. In this review, we discuss the evidence that supports a role of the kinase activity of the receptor in the molecular mechanism of insulin action.Keywords
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