Possible strategies to protect the preterm brain against the fetal inflammatory response
- 1 October 2001
- journal article
- review article
- Published by Wiley in Developmental Medicine and Child Neurology
- Vol. 43 (s89) , 18-20
- https://doi.org/10.1111/j.1469-8749.2001.tb04141.x
Abstract
The accruing evidence that a fetal inflammatory response is the link between antenatal infection and white matter damage in the preterm newborn infant offers room for speculation how this harmful sequence could be interrupted. Enhancement of endogenous protection, response modification, and damage limitation downstream could be helpful strategies for intervention design. Appropriate observational and experimental studies are needed before clinical interventions can be initiated.Keywords
This publication has 23 references indexed in Scilit:
- Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopalliumAnnals of Neurology, 2000
- Maternal Infection, Fetal Inflammatory Response, and Brain Damage in Very Low Birth Weight InfantsPediatric Research, 1999
- Antenatal Glucocorticoid Treatment and Cystic Periventricular Leukomalacia in Very Premature InfantsNew England Journal of Medicine, 1999
- Brain Damage in Preterm Newborns: Might Enhancement of Developmentally Regulated Endogenous Protection Open a Door for Prevention?Pediatrics, 1999
- Matrix Metalloproteinases in Cerebrovascular DiseaseJournal of Cerebral Blood Flow & Metabolism, 1998
- Maternal Intrauterine Infection, Cytokines, and Brain Damage in the Preterm NewbornPediatric Research, 1997
- Ventriculomegaly, delayed myelination, white matter hypoplasia, and “periventricular” leukomalacia: How are they related?Pediatric Neurology, 1996
- Regulation of an oligodendrocyte progenitor cell line by the interleukin‐6 family of cytokinesGlia, 1994
- Preterm Birth and Cerebral Palsy: Is Tumor Necrosis Factor the Missing Link?Developmental Medicine and Child Neurology, 1993
- White matter damage in preterm newborns —an epidemiologic perspectiveEarly Human Development, 1990