Sassafras and herb tea. Potential health hazards

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Abstract
Extensive studies conducted by the Food and Drug Administration (FDA) in 1960 showed that safrole (4-allyl-1,2-methylenedioxybenzene), the major chemical constituent (e.g., up to 80% by weight) of the aromatic oil present in sassafras [Sassafras albidum] root bark, was a hepatocarcinogen in rats. Recognizing the confirmed toxic potential of safrole, the FDA has recently clarified the 1960 ruling in terms that clearly state that safrole and safrole-containing products cannot be recognized as being safe for human use. The consumption of herb tea generally may result in changes in the bioavailability characteristics of concomitantly administered drugs. To ensure safe and effective drug therapy, physicians should evaluate their patients in terms of extemporaneous herb tea usage and discourage these practices whenever feasible.

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