Evidence for Endothelium-Dependent Vasodilation of Resistance Vessels by Acetylcholine
- 1 January 1987
- journal article
- neurohumoral control-of-blood-vessel-tone
- Published by S. Karger AG in Journal of Vascular Research
- Vol. 24 (3) , 145-149
- https://doi.org/10.1159/000158689
Abstract
In the perfused mesenteric arterial vasculature of the rabbit, vasodilation by acetylcholine (ACh) was almost completely blocked after a 15-min perfusion of the vasculature with 0.2% collagenase, an enzyme capable of removing endothelial cells. In the perfused mesenteric arterial vasculature of the rat, vasodilation by ACh was markedly, though not completely, inhibited by hemoglobin (10 µM), an agent which can inactivate endothelium-derived relaxing factor (EDRF). These results suggest that a major component of vasodilation of mesenteric resistance vessels in rabbit and rat by ACh is mediated by EDRF.Keywords
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