Biochemical Aspects of Blood Platelets (Peptidase, nucleotidase, acid and alkaline phosphatase activity in normal subjects, during menstruation and in some hemorrhagic disorders)

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Abstract
Peptidase, nucleotidase, acid and alkaline phosphatase detns. were carried out on blood platelets in normal subjects, during menstruation and in some blood and hemorrhagic disorders. The effect of pH on all 4 enzymes was tested, and the rate of hydrolysis of their substrates estimated. During the 1st 2 days of menstruation a high peptidase activity was found and there was also a marked fall in the alkaline phosphatase level, with a less marked reduction of nucleotidase activity. From the available data, also in blood and hemorrhagic disorders there seems to be a disturbance in platelet protein metabolism, but further observations are necessary in order to confirm these findings.