Functionalization of the methyl group of 2-methylindole by direct generation of a C,N-dianion
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 1,p. 179-180
- https://doi.org/10.1039/p19900000179
Abstract
The first method for directly generating C,N-dianion from an alkyl-substituted π-excessive N-heterocyclic compound (2-methylindole) has been developed. It involves treatment with 3 equiv. of BuLi and 2 equiv. of ButOK in a particular sequence and results in the functionalization of the 2-methyl group of the indole in a regiospecific manner.Keywords
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