THE EFFECTS OF RANITIDINE and CYSTEAMINE ON INTESTINAL METAPLASIA INDUCED BY X‐IRRADIATION IN RATS

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Abstract
The influence of ranitidine and cysteamlne on intestinal metaplasia was examined in 7‐month‐old male Crj: CD (SD) rats. At the age of 5 weeks, the animals were treated with 10 Gy doses of X‐rays at 3‐day intervals up to a total of 20 Gy in the gastric region, and 6 months after irradiation, the rats received either ranitidine (0.02% in diet) or cysteamine (0.1% in drinking water) for 2 months. The incidence and number of intestinal metaplasia with alkaline phosphatase‐positive foci in rats given X‐rays and cysteamlne (group 4) were significantly low compared with those in rats given X‐rays and ranitidine (group 3) (p<0.01). In both the pyloric and the fundic gland mucosae, the average numbers of type C metaplasia (intestinal crypts with Paneth cells) and total numbers of metaplastic foci in rats of group 3 were much higher than those in group 4 (P<0.05). The present results showed that the occurrence of intestinal metaplasia was significantly increased after administration of ranitidine and decreased by cysteamine. ACTA PATHOL JPN 38 : 1285‐1296, 1988.