Getting a Handle on “Good” Cholesterol with the High-Density Lipoprotein Receptor

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Abstract
Plasma lipoproteins transport fats (cholesterol and triglyceride) and hence have a key role in atherosclerotic cardiovascular disease. Low-density lipoprotein (LDL) cholesterol promotes atherogenesis, and high-density lipoprotein (HDL) cholesterol inhibits it. The total and relative amounts of saturated and unsaturated fats in the diet can influence plasma lipoprotein levels and thus the risk of cardiovascular disease. This influence is due, at least in part, to the effects of dietary fats on lipoprotein receptors on the surfaces of cells that bind circulating lipoproteins tightly and mediate the internalization of lipoprotein cholesterol by cells. The discovery of LDL receptors 25 years ago by . . .