EXPERIMENTAL CHRONIC ARTHRITIS (SYNOVITIS)
- 1 December 1933
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 27 (6) , 1065-1071
- https://doi.org/10.1001/archsurg.1933.01170120089002
Abstract
In recent years the allergic hypothesis for the etiology of chronic arthritis, especially the proliferative type, has received considerable attention.1According to this theory, the articular changes are local manifestations of a generalized allergic state. As early as 1902, Menzer2suggested that streptococci first gained access to the joints, but that this did not result in inflammatory changes until antibodies were produced. Further researches by Weintraud,3Henry,4Faber,5Friedberger,6Freiberg,7Klinge8and Gudzent9demonstrated that arthritic changes could be produced in experimental animals by first sensitizing the animal to bacterial or nonbacterial proteins and then by injecting the antigen into the joints. Similar results were obtained if the antigen was injected first into the joint and later into the general circulation. Swift10and his coworkers have recently studied experimental streptococcus allergy in rabbits, with the view of explaining the etiologyKeywords
This publication has 0 references indexed in Scilit: