INHIBITION OF TUMOR VASCULARIZATION BY TRANEXAMIC ACID - EXPERIMENTAL STUDIES ON POSSIBLE MECHANISMS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 1  (5) , 299-304
Abstract
The vascularization of an i.m. transplanted rat sarcoma was studied by microangiography. Administration of tranexamic acid and of indomethacin reduced the vascular connections between tumor and surrounding normal muscle. These drugs reduced tumor growth rate irrespective of whether they were administered early or late during tumor growth. An EM study of tumor specimens from animals given tranexamic acid did not reveal any degenerative vascular changes. One explanation of the inhibition of tumor growth and vascularization by tranexamic acid and by indomethacin may be a reduction of a local inflammatory reaction induced by tumor transplantation and stimulating tumor vascularization.

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