Toward a Versatile Allylation Reagent: Practical, Enantioselective Allylation of Acylhydrazones Using Strained Silacycles
- 18 July 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (32) , 9596-9597
- https://doi.org/10.1021/ja035001g
Abstract
A highly practical method for the enantioselective allylation of acylhydrazones has been developed. The previously reported strained silacycle reagent 1 reacts with a wide variety of acylhydrazones to give the hydrazide products with good enantioselectivity (83−89% ee, typically). It has been demonstrated that the products may be isolated without chromatography by recrystallization in ≥98% ee.Keywords
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