MORPHOLOGICAL ASSESSMENT OF STIMULATORY EFFECT OF COUMARIN ON MACROPHAGES

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 59  (1) , 93-96
Abstract
In examining the migration of macrophages onto subcutaneously implanted coverslips in rats, coumarin (5-6 benzo-.alpha.-pyrone) and a preparation (Venalot) containing the former, very significantly increased the total macrophage number and the percentage of stimulation on the skin side of the coverslip. For the muscle side, Venalot increased the total numbers and the percentage stimulated while coumarin alone had no effect compared with the control. It remains to be seen whether these stimulated macrophages are also activated.