GROWTH-CHARACTERISTICS OF HUMAN COLONIC ADENOCARCINOMAS PROPAGATED IN THE ROWETT ATHYMIC RAT

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (8) , 3111-3115
Abstract
Two human colonic adenocarcinoma cell lines were propagated in the Rowett athymic rat. Line LoVo displayed a well-differentiated morphology and exhibited progressive growth over a 70 day observation period with a doubling time of 8.5 days throughout. No metastatic involvement was noted. Xenografts of SW 620 cells were undifferentiated and highly necrotic. These tumors grew progressively for .apprx. 30 days with a doubling time of 5.5 days, but over 90% of the animals exhibited a spontaneous regression with a mean time to total regression of 51 .+-. 3 (SE) days. Animals which had rejected the SW 620 xenografts would not support the growth of either the SW 620 or LoVo xenografts when challenged a 2nd time with inocula producing a 100% tumor incidence in control rats. No metastatic involvement was noted for the SW 620 xenografts, but the tumors frequently invaded the underlying musculature and protruded into the peritoneal cavity without producing ascites or tumor nodules at sites distant from the primary. Human tumor xenografts are of interest in drug screening studies.