Genotoxicity of Formaldehyde in Cultured Human Bronchial Fibroblasts
- 5 April 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 228 (4695) , 89-91
- https://doi.org/10.1126/science.3975633
Abstract
Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.This publication has 12 references indexed in Scilit:
- Formaldehyde Damage to DNA and Inhibition of DNA Repair in Human Bronchial CellsScience, 1983
- Formaldehyde is mutagenic for cultured human cellsMutation Research/Genetic Toxicology, 1983
- Comparison of mutagenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea in human diploid fibroblastsCarcinogenesis: Integrative Cancer Research, 1983
- Relationship between excision repair and the cytotoxic and mutagenic effect of the ‘anti’ 7,8-diol-9,10-epoxide of benzo[a]pyrene in human cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1982
- DNA Repair EnzymesAnnual Review of Biochemistry, 1982
- Report of the Federal Panel on FormaldehydeEnvironmental Health Perspectives, 1982
- Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblastsNature, 1981
- Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modificationNature, 1980
- Genetic and cytogenetical effects of formaldehyde and related compoundsMutation Research/Reviews in Genetic Toxicology, 1977
- Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and NitrosamidesNature, 1969