“Singapore Green”: A New Fluorescent Dye for Microarray and Bioimaging Applications
- 19 December 2008
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (2) , 405-408
- https://doi.org/10.1021/ol802700w
Abstract
We have synthesized Singapore Green (SG), a structural hybrid of Tokyo Green and Rhodamine 110. This new dye is a green light-emitting substitute for 7-aminocoumarin, a blue fluorescent dye widely used in enzymatic assays. SG-conjugated peptide substrates were successfully synthesized and used in microarray-based protease substrate profiling and live-cell imaging experiments.Keywords
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