IN VITRO EFFECTS OF ETHANOL ON PRIMATE LUTEAL MEMBRANES: EXPOSURE OF ADDITIONAL GONADOTROPIN RECEPTOR SITES

1 April 1982

journal article
research article
Published by The Endocrine Society in Endocrinology

Vol. 110 (4) , 1451-1453
https://doi.org/10.1210/endo-110-4-1451

Abstract

The presence of 0.8–8.0% (vol/vol) ethanol increased the specific binding of [¹²⁵I]human luteinizing hormone (hLH) to membrane particulate fractions prepared from the rhesus monkey corpus luteum in a dose-dependent manner. Ethanol increased the number of available gonadotropin binding sites without altering their affinity for LH. These results suggest that (1) there are additional gonadotropin receptors in the macaque corpus luteum which are not detected by conventional in vitro techniques, and (2) ethanol exposes receptors previously unavailable for hormone interaction.

Keywords

PRIMATES
RECEPTORS
GONADOTROPIN
ETHANOL
BINDING SITES
MACACA
LUTEINIZING HORMONE
AFFINITY
LYMPHOHISTIOCYTOSIS
HEMOPHAGOCYTIC

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